Neuroscience 222: Brain Imaging and Brain Stimulation

Spring 2022

Tuesdays and Thursdays, noon - 1:50pm

Bunche Hall 2150

Faculty

Course description and learning outcomes

Lectures

Course assignments

Student evaluation:

Inclusive classroom interaction and environment

CCLE Website:

Assigned Reading:

Lectures

1. Neuroanatomy
   
   • No assigned reading, but Prof. MacKenzie-Graham recommends The Human Brain Coloring Book by Marian Diamond and Arne Scheibel as an excellent reference for learning neuroanatomy.
   • If you want to know more about Marian Diamond, there is a documentary about her called My Love Affair With the Brain: The Life and Science of Dr. Marian Diamond (this is just a clip from it).
2. MR Physics
   
   • Grover VPB, Tognarelli JM, Crossey MME , Cox IJ, Taylor-Robinson SD, McPhail MJW (2015) Magnetic Resonance Imaging: Principles and Techniques: Lessons for Clinicians J Clin Exp Hepatol 5(3):246-55. doi: 10.1016/j.jceh.2015.08.001.
   • Pooley RA (2005) AAPM/RSNA physics tutorial for residents: fundamental physics of MR imaging Radiographics 25(4):1087-99. doi: 10.1148/rg.254055027.
3. Structural and Diffusion MRI
   
   • Jbabdi S (2009) "Chapter 21 - Imaging Structure and Function", Editor(s): Heidi Johansen-Berg, Timothy E.J. Behrens, Diffusion MRI, Academic Press, 2009, pp461-480, https://doi.org/10.1016/B978-0-12-374709-9.00021-3.
   • Tournier J-D, Mori S, Leemans A (2011) Diffusion Tensor Imaging and Beyond Magnetic Resonance in Medicine 65:1532–1556 https://doi.org/10.1002/mrm.22924
4. Positron Emission Tomography & Functional Magnetic Resonance Imaging
   4a. PET
   • Badawi RD, Shi H, Hu P, Chen S, Xu T, Price PM, Ding Y, Spencer BA, Nardo L, Liu W, Bao J, Jones T, Li H, Cherry SR. First Human Imaging Studies with the EXPLORER Total-Body PET Scanner (2019) Journal of Nuclear Medicine 60(3):299-303. https://doi.org/10.2967/jnumed.119.226498
   • Tripathi SM, Murray AD (2021) Alzheimer’s Dementia: The Emerging Role of Positron Emission Tomography Neuroscientist 2021 Mar 4 ;1073858421997035 https://doi.org/10.1177/1073858421997035
4b. fMRI
• Monti MM (2011) Statistical analysis of fMRI time-series: a critical review of the GLM approach Front. Hum. Neurosci. 18 March 2011; 5:28 https://doi.org/10.3389/fnhum.2011.00028
• Crone JS,Lutkenhoff ES, Bio BJ, Laureys S, Monti MM (2017) Testing Proposed Neuronal Models of Effective Connectivity Within the Cortico-basal Ganglia-thalamo-cortical Loop During Loss of Consciousness Cerebral Cortex, 27(4):2727–2738, https://doi.org/10.1093/cercor/bhw112
• MM Monti, ES Lutkenhoff, M Rubinov, Boveroux P, Vanhaudenhuyse A, Gosseries O, Bruno M-A, Noirhomme Q, Boly M, Laureys S (2013) Dynamic change of global and local information processing in propofol-induced loss and recovery of consciousness. PLoS Comput Biol. 2013;9(10):e1003271. https://doi.org/10.1371/journal.pcbi.1003271
5. Shape Analysis
   • Ashburner J (2009) Computational anatomy with the SPM software. Magnetic Resonance Imaging. 27(8)1163-1174. https://doi.org/10.1016/j.mri.2009.01.006
   • Thompson P and Toga A (2002) A framework for computational anatomy. Computing and Visualization in Science 5:13–34. https://doi.org/10.1007/s00791-002-0084-6
6. Transcranial Direct Current Stimulation (tDCS) & Head Modeling/Simulation
• Nitsche MA, Paulus W (2000) Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation Journal of Physiology 527.3:633–9. http://dx.doi.org/10.1111/j.1469-7793.2000.t01-1-00633.x
• Jog MS, Kim E, Anderson C, Kubicki A, Kayathi R, Jann K, Yan L, Leaver A, Hellemann G, Iacoboni M, Woods RP, Wang DJJ, Narr KL (2021) In-vivo imaging of targeting and modulation of depression-relevant circuitry by transcranial direct current stimulation: a randomized clinical trial Translational Psychiatry 11(1):138. https://doi.org/10.1038/s41398-021-01264-3
7. Transcranial Magnetic Stimulation (TMS)
   7a. TMS Foundations, Physiology, and Circuitry
   • Merton PA, Morton HB. Stimulation of the cerebral cortex in the intact human subject. Nature. 1980 May 22;285(5762):227. PMID: 7374773 http://dx.doi.org/10.1038/285227a0
   • Barker AT, Jalinous R, Freeston IL. Non-invasive magnetic stimulation of human motor cortex. Lancet. 1985 May 11;1(8437):1106–1107. PMID: 2860322 http://dx.doi.org/10.1016/s0140-6736(85)92413-4
   • Pascual-Leone A, Walsh V. Fast backprojections from the motion to the primary visual area necessary for visual awareness. Science. 2001 Apr 20;292(5516):510–512. PMID: 11313497 http://dx.doi.org/10.1126/science.1057099
   7b. TMS Perturbation and Mapping
   • Paus T, Jech R, Thompson CJ, Comeau R, Peters T, Evans AC. (1997) Transcranial magnetic stimulation during positron emission tomography: a new method for studying connectivity of the human cerebral cortex. J Neurosci. 17(9):3178–3184. PMCID: PMC6573635 doi:10.1523/JNEUROSCI.17-09-03178.1997
   • Strafella AP, Paus T, Barrett J, Dagher A. (2001) Repetitive transcranial magnetic stimulation of the human prefrontal cortex induces dopamine release in the caudate nucleus. J Neurosci. 2001 Aug 1;21(15):RC157. PMCID: PMC6762641 doi: 10.1523/JNEUROSCI.21-15-j0003.2001
   • Massimini M, Ferrarelli F, Huber R, Esser SK, Singh H, Tononi G. (2005) Breakdown of cortical effective connectivity during sleep. Science 309(5744):2228–2232. PMID: 16195466 doi:10.1126/science.1117256
   8a. TMS Treatment and Safety
• Huang Y-Z, Edwards MJ, Rounis E, Bhatia KP, Rothwell JC (2005) Theta burst stimulation of the human motor cortex. Neuron. 45(2):201–206. PMID: 15664172 http://dx.doi.org/10.1016/j.neuron.2004.12.033
• Fox MD, Buckner RL, Liu H, Chakravarty MM, Lozano AM, Pascual-Leone A. (2014) Resting-state networks link invasive and noninvasive brain stimulation across diverse psychiatric and neurological diseases. Proceedings of the National Academy of Sciences. 111(41):E4367–E4375. http://dx.doi.org/10.1073/pnas.1405003111
• Rossi S, Antal A, Bestmann S, Bikson M, Brewer C, Brockmöller J, Carpenter LL, Cincotta M, Chen R, Daskalakis JD, Di Lazzaro V, Fox MD, George MS, Gilbert D, Kimiskidis VK, Koch G, Ilmoniemi RJ, Lefaucheur JP, Leocani L, Lisanby SH, Miniussi C, Padberg F, Pascual-Leone A, Paulus W, Peterchev AV, Quartarone A, Rotenberg A, Rothwell J, Rossini PM, Santarnecchi E, Shafi MM, Siebner HR, Ugawa Y, Wassermann EM, Zangen A, Ziemann U, Hallett M. (2021) Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on training, ethical and regulatory issues: Expert Guidelines. Clin Neurophysiol. 132(1):269–306. PMID: 33243615 http://dx.doi.org/10.1016/j.clinph.2020.10.003
8. 8b. Transcranial Ultrasound (tUS)
• Badran BW, Caulfield KA, Stomberg-Firestein S, Summers PM, Dowdle LT, Savoca M, Li X, Austelle CW, Short EB, Borckardt JJ, Spivak N, Bystritsky A, George MS (2020) Sonication of the anterior thalamus with MRI-Guided transcranial focused ultrasound (tFUS) alters pain thresholds in healthy adults: A double-blind, sham-controlled study. Brain Stimulation 13(6):1805–12. http://dx.doi.org/10.1016/j.brs.2020.10.007
• Folloni D, Verhagen L, Mars RB, Fouragnan E, Constans C, Aubry J-F, Rushworth MFS, Sallet J (2019) Manipulation of Subcortical and Deep Cortical Activity in the Primate Brain Using Transcranial Focused Ultrasound Stimulation. Neuron 101(6):1109–16.e5. http://dx.doi.org/10.1016/j.neuron.2019.01.019
9. Intracranial Electrophysiology and Deep Brain Stimulation
   • Krauss JK, Lipsman N, Aziz T, Boutet A, Brown P, Chang JW, Davidson B, Grill WM, Hariz MI, Horn A, Schulder M, Mammis A, Tass PA, Volkmann J, Lozano AM (2021) Technology of deep brain stimulation: current status and future directions. Nat Rev Neurol 17, 75–87. https://doi.org/10.1038/s41582-020-00426-z
   • Parvizi and Kastner (2018) Promises and limitations of human intracranial electroencephalography. Nat Neurosci 21, 474–483. https://doi.org/10.1038/s41593-018-0108-2